Vascular Endothelium, Hemodynamic Forces, and Atherogenesis
نویسندگان
چکیده
منابع مشابه
Commentary Vascular Endothelium, Hemodynamic Forces, and Atherogenesis
Intimal lipid accumulation, hyperplasia, and scarring are stigmata of atherosclerotic vascular disease, whose major complications—myocardial and cerebral ischemia and infarction—continue to be major health problems in developed nations. This insidiously progressive disease typically spans decades, but can reach a clinical horizon in a matter of minutes due to critical changes in a given atheros...
متن کاملHemodynamic forces in endothelial dysfunction and vascular aging.
Aging is a key risk factor associated with the onset of cardiovascular disease. Notably, vascular aging and cardiovascular disease are both associated with endothelial dysfunction, or a marked decrease in production and bioavailability the vasodilator of nitric oxide (NO). As a result of decreased nitric oxide availability, aging vessels often exhibit endothelial cell senescence and increased o...
متن کاملShear Forces Enhance Toxoplasma gondii Tachyzoite Motility on Vascular Endothelium
Toxoplasma gondii is a highly successful parasite that infects approximately one-third of the human population and can cause fatal disease in immunocompromised individuals. Systemic parasite dissemination to organs such as the brain and eye is critical to pathogenesis. T. gondii can disseminate via the circulation, and both intracellular and extracellular modes of transport have been proposed. ...
متن کاملHemodynamic Forces Regulate Embryonic Stem Cell Commitment to Vascular Progenitors
Pluripotent embryonic stem can (ES) cells can differentiate into all cell lineages. During the process of embryonic development, ES cells are exposed to fluid flow or blood flow generated by the contracting heart. Absence of fluid flow results in the formation of abnormal cardiac chambers and valve formation. Thus, hemodynamic forces and ES cell differentiation to vascular progenitor cells (VPC...
متن کاملPeroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis.
OBJECTIVE Peroxynitrite, a potent oxidant generated by the reaction of NO with superoxide, has been implicated in the promotion of atherosclerosis. We designed this study to determine whether peroxynitrite induces its proatherogenic effects through induction of endoplasmic reticulum (ER) stress. METHODS AND RESULTS Human vascular endothelial cells treated with Sin-1, a peroxynitrite generator...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 1999
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)65090-0